Lack of hormones! Please help?

I had a radical hysterectomy 1 year ago. I was put on Premarin...Did well for a while, but now things are horrible. My symptoms are mood swings, low energy, trouble sleeping, not feeling like myself, mental confusion (really bad), feel like I'm in a fog, etc. Another gen. practitioner gave me some information on Bio-identical Hormone replacement therapy and it sounds promising. Anyone have experience with them. Also, how much does the lack of pregestin play in my mental state? Please help, I feel miserable. I do not want to be social and i feel as though I'm ignoring EVERYBODY...